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The 193 function domain repeats in human proteins



Domain repeats frequently observed (> 10 human proteins)

S.NO Select Domain Repeat name Number of Proteins
1 Ig-like C2-type 205
2 EF-hand 186
3 Fibronectin type-III 136
4 Cadherin 114
5 RRM 103
6 EGF-like 100
7 C2 60
8 LIM zinc-binding 51
9 SH3 46
10 Ig-like 44
11 Sushi 43
12 TSP type-1 43
13 PDZ 42
14 PH 36
15 CUB 35
16 ABC transporter 32
17 IQ 32
18 WW 29
19 Collagen-like 28
20 Calponin-homology (CH) 27
21 Laminin EGF-like 27
22 LDL-receptor class A 27
23 KH 24
24 Ig-like V-type 23
25 Laminin G-like 21
26 PAS 19
27 CBS 18
28 VWFC 18
29 ABC transmembrane type-1 16
30 UIM 16
31 VWFA 16
32 Beta or gamma crystallin Greek key 15
33 NBPF 15
34 Protein kinase 14
35 SAM 13
36 SRCR 13
37 BRCT 12
38 DRBM 12
39 IPT/TIG 12
40 Tudor 12
41 VWFD 12
42 Bromo 11
43 LRRCT 11
44 BTB 10
45 MIR 10
46 SH2 10
Domain repeats less obserevd (<10 human proteins)

S.NO Select Domain Repeat Types Number of Proteins
1 Chromo 9
2 Doublecortin 9
3 SANT 9
4 Thioredoxin 9
5 Tyrosine-protein phosphatase 9
6 Kazal-like 8
7 Link 8
8 BPTI/Kunitz inhibitor 7
9 Calx-beta 7
10 GAF 7
11 Kringle 7
12 L27 7
13 RanBD1 7
14 UBA 7
15 EamA 6
16 EH 6
17 F5/8 type C 6
18 FF 6
19 Galectin 6
20 KRAB 6
21 LRRNT 6
22 PLD phosphodiesterase 6
23 Ubiquitin-like 6
24 CAP-Gly 5
25 CMP/dCMP-type deaminase 5
26 C-type lectin 5
27 Fibronectin type-II 5
28 HotDog ACOT-type 5
29 HTH myb-type 5
30 MAM 5
31 Plastocyanin-like 5
32 PSI 5
33 SMB 5
34 WAP 5
35 WH2 5
36 ZU5 5
37 Albumin 4
38 DAZ-like 4
39 FAS1 4
40 GoLoco 4
41 GRAM 4
42 Guanylate cyclase 4
43 Hexokinase 4
44 Ig-like C1-type 4
45 Peptidase S1 4
46 PID 4
47 PKD 4
48 PPIase FKBP-type 4
49 PQ-loop 4
50 P-type 4
51 SEA 4
52 STI1 4
53 Thyroglobulin type-1 4
54 WWE 4
55 4Fe-4S ferredoxin-type 3
56 Agenet-like 3
57 CARD 3
58 DED 3
59 DEP 3
60 DUSP 3
61 F5/8 type A 3
62 Follistatin-like 3
63 HTH OST-type 3
64 Macro 3
65 MAGE 3
66 Myb-like 3
67 NHR 3
68 PAH 3
69 POLO box 3
70 PWWP 3
71 REM-1 3
72 Saposin B-type 3
73 SEC63 3
74 SIS 3
75 Transferrin-like 3
76 t-SNARE coiled-coil homology 3
77 UPAR/Ly6 3
78 VOC 3
79 ACT 2
80 ADF-H 2
81 Anaphylatoxin-like 2
82 Apple 2
83 ATP-grasp 2
84 BAH 2
85 BEN 2
86 CHCH 2
87 CHORD 2
88 Death 2
89 DH 2
90 DM10 2
91 EXPERA 2
92 Helicase ATP-binding 2
93 HMA 2
94 KOW 2
95 LCCL 2
96 MARVEL 2
97 MIB/HERC2 2
98 Miro 2
99 PAP-associated 2
100 Ras-associating 2
101 RBD 2
102 RGS 2
103 Rhodanese 2
104 RNase III 2
105 RUN 2
106 SAM-dependent MTase PRMT-type 2
107 SAP 2
108 Saposin A-type 2
109 WSC 2
110 AIG1-type G 1
111 AKAP 1
112 BAG 1
113 BSD 1
114 C1q 1
115 Cache 1
116 CS 1
117 CSD 1
118 CUE 1
119 Cystatin fetuin-A-type 1
120 Cystatin fetuin-B-type 1
121 Cystatin kininogen-type 1
122 Cystatin 1
123 DDE-1 1
124 Fibronectin type-I 1
125 FZ 1
126 Glutaredoxin 1
127 H15 1
128 HARP 1
129 HIN-200 1
130 IPT/TIG; atypical 1
131 ITAM 1
132 KIND 1
133 LDL-receptor class A; atypical 1
134 Lipoyl-binding 1
135 MI 1
136 MIF4G 1
137 MIT 1
138 MtN3/slv 1
139 Pentapeptide repeat 1
140 PLAT 1
141 PRKCSH 1
142 Rieske 1
143 S1 motif 1
144 SPAZ 1
145 SUEL-type lectin 1
146 TNase-like 1
147 WHEP-TRS 1